High florbetaben uptake and Alzheimer’s disease

September 12, 2012

According to a study carried out by researchers from the Centre for PET at Austin Health in Melbourne and Bayer Healthcare using florbetaben-PET imaging on 45 subjects with mild cognitive impairment (MCI), progression to Alzheimer’s disease occurred in 75%of MCI with high florbetaben uptake, compared with 53% of MCI with hippocampal atrophy.Furthermore they also found that 80% of MCI with both high florbetaben uptake and hippocampal atrophy progressed to Alzheimer’s, while 19% of MCI subjects with low florbetaben developed other dementias. The researchers concluded that high florbetaben binding indicated a “very high risk of progression from mild cognitive impairment to Alzheimer’s within two years and was a stronger and more specific risk factor than hippocampal atrophy in this cohort.” For more information, refer to the Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

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